I was having some difficulty cutting extruded Plexiglas and damaged 3 cutters in the process. Based on suggestions made by previous posters I used 2000mm/min for the profile speed. Makita spindle speed position 3 (whatever the rpm is) and depth of cut 0.2mm (.008"). Two flute up cutter 1/4" dia. It took a while, 50 circuits to cut 10 mm thk material. Continuous Vacuuming of the profile. Came up with an acceptable finish, and no clumping of molten acrylic. Would probably do even better with a higher feed … 2500 - 3000 mm/min perhaps.